As I indicated in my response to acroyear70, I can believe that some people (maybe a lot of people) can taste/feel a difference. That wasn't really the point of my post. There are a lot of websites spreading disinformation about HFCS which is just plain silly, so I'm trying to counter that.

Oh, for what it's worth, "real" corn syrup is almost pure glucose (and water, of course). The current Karo syrup uses a combination of glucose syrup and HFCS to increase sweetness.